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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Liver failure is a severe condition characterized by extensive hepatocyte damage&#44; leading to the loss of liver function&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> This condition can precipitate multi-organ dysfunction and life-threatening complications&#46; Worsening renal function &#40;WRF&#41; is a common complication observed in patients with liver failure receiving treatment in intensive care units &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The renal system is the most frequently affected organ&#47;system in the context of multi-organ failure in patients with liver failure&#44; with approximately 56&#37; of patients experiencing renal impairment&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> WRF in this population is associated with elevated mortality rates and an increased chronic kidney disease risk&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> As a result&#44; the early identification and prevention of liver failure in ICU patients at risk of WRF hold significant clinical importance&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In patients with liver failure&#44; structural changes and distortion in the liver can increase intrahepatic vascular resistance&#46; This leads to the release of potent vasodilators&#44; triggering systemic arterial vasodilation&#44; resulting in inadequate arterial filling and reduced renal blood flow&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> Liver failure is characterized by dilation of visceral arterial vessels&#44; leading to a decrease in systemic vascular resistance&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> This can increase the synthesis of vasodilators&#44; resulting in more pronounced vasodilation that cannot be compensated for by an increase in cardiac output &#40;CO&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> A reduction in the effective blood volume within the systemic circulation may lead to decreased intravascular blood volume&#44; potentially resulting in decreased renal blood flow&#46; Ultimately&#44; these hemodynamic changes within the kidneys and alterations in renal autoregulation may contribute to WRF&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Moreover&#44; during liver failure&#44; the activation of systemic vasoconstrictor systems&#8212;including the renin-angiotensin-aldosterone system&#44; sympathetic nervous system&#44; and vasopressin&#8212; can induce renal vasoconstriction&#46; This occurs even in the presence of an elevated CO&#44; further contributing to WRF&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Studies suggested that the primary cause of acute kidney injury &#40;AKI&#41; in patients with liver cirrhosis is hypovolemia &#40;&#8764;50&#37;&#41;&#44; resulting in reduced perfusion&#46; This is followed by intrinsic renal factors such as acute tubular necrosis &#40;&#8764;30&#37;&#41; and hepatorenal syndrome &#40;&#8764;20&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;14</span></a> The relationship between early blood pressure decline and WRF has been moderately studied in patients with acute heart failure &#40;AHF&#41;&#46; WRF in hospitalized patients with AHF is associated with adverse clinical outcomes and can be predicted by a decline in systolic blood pressures &#40;SBP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Notably&#44; a pronounced early SBP decline is associated with increased WRF&#44; worsening heart failure&#44; and increased cardiovascular mortality risk at 180 days&#46; Interestingly&#44; the relationship between SBP decline and prognoses remains consistent&#44; irrespective of the WRF presence&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> To date&#44; no studies have investigated the prognostic implications of early blood pressure decline&#8212;encompassing SBP&#44; diastolic blood pressure &#40;DBP&#41;&#44; and mean arterial pressure &#40;MAP&#41;&#8212;and its association with WRF in ICU patients with liver failure&#44; despite the concurrent occurrence of these events&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Therefore&#44; the present study aimed to investigate the relationship between early blood pressure decline and WRF&#44; as well as the clinical outcomes in ICU patients with liver failure&#46; The findings of this study are expected to contribute to the early identification and intervention of WRF in ICU patients with liver failure&#44; providing a scientific basis for clinical management strategy development and potentially improving patient prognoses&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Patients and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Data source</span><p id="par0020" class="elsevierStylePara elsevierViewall">This study used the Medical Information Mart for Intensive Care IV &#40;MIMIC-IV&#41; version 2&#46;2 database&#46; MIMIC IV is a large-scale clinical database that includes the detailed medical records of tens of thousands of ICU patients&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Access to this database can be obtained through legitimate channels&#44; and detailed information can be found on its official website &#40;<a href="https://mimic.mit.edu">https&#58;&#47;&#47;mimic&#46;mit&#46;edu</a>&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Study population</span><p id="par0025" class="elsevierStylePara elsevierViewall">All patients in the MIMIC IV database were included in the study&#46; The inclusion criteria were as follows&#58; &#40;1&#41; admission to the ICU for the first time during their first hospitalization&#59; &#40;2&#41; diagnosis of liver failure according to the International Classification of Diseases &#40;ICD&#41;&#44; Ninth Revision &#40;ICD-9&#41;&#44; and Tenth Revision &#40;ICD-10&#41; codes&#46; &#40;Table S1&#41;&#59; and &#40;3&#41; age &#8805;18 years&#46; Patients with a peak SBP drop of &#60;0&#8239;mmHg were excluded&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Data extraction</span><p id="par0030" class="elsevierStylePara elsevierViewall">We extracted demographics&#44; comorbidities&#44; vital signs&#44; and laboratory results from the MIMIC IV database using Structured Query Language and tools such as Navicat&#46; Comorbidities were identified through ICD-9&#47;10 codes &#40;Table S1&#41;&#46; The following tables from the MIMIC IV database were used&#58; &#34;diagnoses&#95;icd&#44;&#34; &#34;labevents&#44;&#34; &#34;patients&#44;&#34; &#34;chartevents&#44;&#34; and &#34;ICUstays&#46;&#34; The average blood pressure value measured within the first hour after ICU admission was taken as the baseline SBP&#46; The recorded creatinine value at the first monitoring after ICU admission was considered the baseline creatinine level&#46; Additionally&#44; the average of the highest and lowest laboratory indices values obtained within 24&#8239;h after ICU admission were used to determine the baseline values for laboratory indices&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Exposure and outcomes</span><p id="par0035" class="elsevierStylePara elsevierViewall">Peak SBP drop was defined as the difference between the baseline and the lowest values recorded within the first 48&#8239;h of the study period&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> For example&#44; if the baseline SBP was 150&#8239;mmHg and the lowest SBP within 48&#8239;h was 125&#8239;mmHg&#44; the drop in peak SBP would be 25&#8239;mmHg &#40;not &#8722;25&#8239;mmHg&#41;&#46; WRF was defined as an increase in serum creatinine levels by &#8805;0&#46;3&#8239;mg&#47;dL from baseline to any point on day 5&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Sixty-day in-hospital survival was defined as the duration between admission to the ICU and either in-hospital death or loss to follow-up at the study&#8217;s conclusion&#44; whichever happened first&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Statistical analysis</span><p id="par0040" class="elsevierStylePara elsevierViewall">Baseline characteristics were summarized according to the peak SBP drop tertiles within the first 48&#8239;h of the study period&#46; Normally distributed data are presented as means&#8239;&#177;&#8239;standard deviations&#44; skewed variables as medians &#40;interquartile ranges&#41;&#44; and categorical variables as frequencies &#40;percentages&#41;&#46; Analysis of variance was used for normally distributed variables&#44; the Kruskal-Wallis test was used for skewed variables&#44; and the chi-squared test was used for categorical variables&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To evaluate the determinants of peak SBP decline&#44; a multivariate linear regression model was developed to assess the decline in SBP within 48&#8239;h using baseline clinical characteristics and routine laboratory parameters of the patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Cox proportional hazard models were constructed to determine the relationship between peak blood pressure decline and both WRF and 60-day in-hospital mortality&#46; In the multivariate models&#44; adjustment for covariates was performed by introducing covariates into the baseline model or excluding covariates from the full model if they induced more than 10&#37; alteration in the regression coefficient of the independent variable&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">A generalized additive model was used to explore the potential nonlinear relationship between the peak blood pressure drop and WRF&#46; Hierarchical Cox regression models were used for subgroup analyses&#44; and likelihood ratio tests were conducted to evaluate the interactions among the subgroups&#46; Kaplan&#8211;Meier curves were analyzed using the log-rank test&#46; Statistical analyses were performed using the R version 4&#46;3&#46;2 &#40;<a href="http://www.R-project.org">http&#58;&#47;&#47;www&#46;R-project&#46;org</a>&#41;&#46; The two-sided significance level was set at 0&#46;05&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Results</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Patient characteristics</span><p id="par0060" class="elsevierStylePara elsevierViewall">Among the 1&#44;062 patients with liver failure who were admitted to ICUs for the first time&#44; 1&#44;039 adult patients experienced an early drop in peak SBP&#44; and these patients were included in the final cohort of this study&#46; The patient screening process is illustrated in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Baseline characteristics and outcomes are succinctly encapsulated according to peak SBP decrease tertiles within the MIMIC IV dataset&#44; as delineated in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Compared to patients in the low tertile&#44; those in the high tertile of peak SBP drop were more likely to exhibit the following characteristics&#58; heart failure&#59; older age&#59; rapid respiratory rate&#59; elevated heart rate&#59; higher baseline SBP&#44; DBP&#44; and MAP levels&#59; increased levels of alanine aminotransferase&#44; lactate dehydrogenase&#44; potassium&#44; and sodium&#59; lower levels of alkaline phosphatase&#44; and total bilirubin&#59; and a higher risk of developing WRF&#46; Additionally&#44; they had a higher mortality rate &#40;60 days&#41; during their hospital stays&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Predictors of SBP drop within 48&#8239;h from baseline</span><p id="par0065" class="elsevierStylePara elsevierViewall">Table S2 presents the factors associated with the peak SBP drop in the univariate and multivariate linear regression analyses&#46; Within the multivariate linear regression analysis&#44; baseline SBP emerged as the strongest predictor of a greater drop in peak SBP within 48&#8239;h&#46; Other independent predictors of a greater SBP decrease included older age&#44; elevated heart rate&#44; increased respiratory rate&#44; higher international normalized ratio &#40;INR&#41;&#44; respiratory failure&#44; and elevated serum potassium levels&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Relationship between SBP drop and WRF</span><p id="par0070" class="elsevierStylePara elsevierViewall">Figure <a class="elsevierStyleCrossRef" href="#sec0115">S1</a> displays the survival curves of the WRF model stratified by the peak SBP drop tertiles within 48&#8239;h&#46; The results indicated that patients in the high tertile of peak SBP drop were more likely to develop WRF&#46; In the multivariate Cox regression analysis&#44; accounting for potential confounders including baseline SBP &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44; a drop in peak SBP was positively associated with WRF &#40;hazard ratio &#91;HR&#93;&#58; 1&#46;08 per 10&#8239;mmHg drop&#44; 95&#37; confidence interval &#91;CI&#93;&#58; 1&#46;03&#44; 1&#46;13&#41;&#46; Within fully adjusted model 3&#44; the HR and 95&#37; CI for the high and middle tertiles with respect to dipped peak SBP were 1&#46;63 &#40;1&#46;26&#44; 2&#46;10&#41; and 1&#46;26 &#40;1&#46;00&#44; 1&#46;59&#41;&#44; respectively&#44; compared to the low tertile &#40;P for trend &#60;0&#46;001&#41;&#46;We used generalized additive models to evaluate the relationship between the peak blood pressure drop and WRF &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; This analysis showed a sustained positive correlation between early peak SBP&#44; and WRF after adjusting for potential confounders with no threshold effect observed &#40;P-nonlinear &#62;0&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Subgroup analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">To examine the correlation between early peak SBP drop and WRF occurrence&#44; we conducted subgroup analyses&#46; Patients were stratified based on age&#44; sex&#44; race&#44; body mass index &#40;BMI&#41;&#44; baseline blood pressure&#44; and comorbidities to discern potential risk factors and identify any special population that might influence this association&#46; The results from the subgroup analysis revealed no significant interaction between a greater drop in early peak SBP and a high risk for WRF across all subgroups &#40;P&#8239;&#62;&#8239;0&#46;05 for all interactions&#44; Figure <a class="elsevierStyleCrossRef" href="#sec0115">S2</a>&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Relationship between SBP drop and prognosis</span><p id="par0080" class="elsevierStylePara elsevierViewall">To determine whether the impact of greater SBP drops on prognosis is mediated by the occurrence of WRF&#44; patients were categorized into four groups&#58; peak SBP drop&#8239;&#8804;&#8239;median without WRF &#40;n&#8239;&#61;&#8239;294&#41;&#44; peak SBP drop&#8239;&#8804;&#8239;median with WRF &#40;n&#8239;&#61;&#8239;221&#41;&#44; peak SBP drop&#8239;&#62;&#8239;median without WRF &#40;n&#8239;&#61;&#8239;232&#41;&#44; and peak SBP drop&#8239;&#62;&#8239;median with WRF &#40;n&#8239;&#61;&#8239;292&#41;&#46; Kaplan-Meier curve analysis for 60-day in-hospital mortality showed significant differences among the groups&#44; with increased mortality rates observed in patients with peak SBP drops above the median and in those with WRF &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; In the adjusted Cox regression analysis &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#44; a 10&#8239;mmHg decline in peak SBP correlated with a 14&#37; rise in the 60-day in-hospital mortality risk &#40;P&#8239;&#60;&#8239;0&#46;001&#41;&#46; Furthermore&#44; we found that patients presenting with both WRF and an early peak SBP drops above the median exhibited the highest 60-day mortality risk &#40;HR &#91;95&#37; CI&#93;&#8239;&#61;&#8239;2&#46;99 &#91;2&#46;21&#44; 4&#46;04&#93;&#44; P&#8239;&#60;&#8239;0&#46;001&#41;&#46; This was followed by patients without WRF&#44; yet with an early peak SBP drop above the median &#40;HR &#91;95&#37; CI&#93;&#8239;&#61;&#8239;2&#46;29 &#91;1&#46;62&#44; 3&#46;22&#93;&#44; P&#8239;&#60;&#8239;0&#46;001&#41;&#44; and lastly&#44; patients with WRF and an early peak SBP drop at or below the median &#40;HR &#91;95&#37; CI&#93;&#8239;&#61;&#8239;1&#46;34 &#91;0&#46;98&#44; 1&#46;83&#93;&#44; P&#8239;&#61;&#8239;0&#46;035&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Relationship between peak DBP and MAP drop and WRF and 60-day in-hospital mortality</span><p id="par0085" class="elsevierStylePara elsevierViewall">To delve deeper into the correlation between early blood pressure decline and clinical outcomes among ICU patients with liver failure&#44; we examined two other commonly utilized blood pressure parameters alongside SBP&#46; After accounting for potential confounding factors&#44; a decrease of 10&#8239;mmHg in the DBP was linked to an HR of 1&#46;11 &#40;95&#37; CI&#58; 1&#46;02&#44; 1&#46;20&#59; P&#8239;&#61;&#8239;0&#46;013&#41; for WRF&#44; as well as an HR of 1&#46;20 &#40;95&#37; CI&#58; 1&#46;10&#44; 1&#46;32&#59; P&#8239;&#60;&#8239;0&#46;001&#41; for mortality within a 60-day hospitalization period&#46; Similarly&#44; a 10&#8239;mmHg reduction in the MAP was associated with an HR of 1&#46;11 &#40;95&#37; CI&#58; 1&#46;04&#44; 1&#46;19&#59; P&#8239;&#61;&#8239;0&#46;004&#41; for WRF&#44; as well as an HR of 1&#46;44 &#40;95&#37; CI&#58; 1&#46;34&#44; 1&#46;55&#59; P&#8239;&#60;&#8239;0&#46;001&#41; for 60-day in-hospital mortality &#40;Table S3&#41;&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">This retrospective cohort study using the MIMIC-IV database found that for every 10&#8239;mmHg drop in early peak blood pressure &#40;SBP&#44; DBP&#44; and MAP&#41; in ICU patients with liver failure&#44; the risk of developing WRF increased by 8&#37;&#44; 11&#37;&#44; and 11&#37;&#44; respectively&#46; This correlation was independent of the patient&#39;s baseline clinical characteristics&#44; including baseline blood pressure&#46; In addition&#44; a 10&#8239;mmHg drop in early peak blood pressure &#40;SBP&#44; DBP&#44; MAP&#41; was associated with a 14&#37;&#44; 20&#37;&#44; and 44&#37; increased risk of 60-day hospital mortality&#44; respectively&#46; These findings underscore the importance of blood pressure monitoring and management in patients with liver failure&#46; Clinicians should remain vigilant in identifying patients at risk of experiencing a substantial early drop in blood pressure&#44; as this may indicate a higher likelihood of developing WRF and subsequent adverse outcomes&#46; Strategies to prevent or mitigate this drop in blood pressure&#44; such as optimizing fluid status and adjusting medication regimens&#44; may improve patient outcomes&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In addition to examining the link between an early peak blood pressure drop and the risk and prognosis of WRF in ICU patients with liver failure&#44; we identified independent predictors of an early drop in peak SBP&#46; These factors included older age&#44; increased respiratory rates&#44; elevated heart rates&#44; elevated INRs&#44; elevated blood potassium levels&#44; and concomitant respiratory failure&#46; However&#44; the strongest predictor of a drop in peak SBP is its baseline level&#46; Our findings are consistent with those of previous studies concerning predictors of early SBP drop in patients with AHF&#44; in which a higher baseline SBP was the strongest predictor&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;18&#44;19</span></a> However&#44; it is important to note that this finding may be attributed to &#34;regression toward the mean&#34; rather than specific pathophysiologic mechanisms&#44; which makes predicting early SBP drops based on patient characteristics challenging&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Our subgroup analysis revealed a consistent association between an early drop in SBPs and the WRF risk across all subgroups &#40;age&#44; sex&#44; BMI&#44; race&#44; baseline SBP&#44; and comorbidities&#41;&#44; indicating the stability of this relationship within each subgroup&#46; Previous studies have indicated a significant positive correlation between baseline SBP and WRF risk&#46; However&#44; when considering these factors in a multivariate regression model&#44; an early SBP drop&#44; rather than baseline SBP levels&#44; was independently linked to a higher risk of WRF&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> In our study&#44; the connection between an early peak SBP drop and a heightened WRF risk persisted within the subgroups with higher baseline SBP and hypertension&#46; This suggests that in clinical practice&#44; a significant early drop in SBP should be avoided&#44; even in patients with higher baseline SBP or concomitant hypertension in ICU patients with liver failure&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Portal hypertension is a key feature of disease progression in cirrhosis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> A previous study by Garg et al&#46; revealed that the baseline hepatic venous pressure gradient &#40;HVPG&#41; is a predictor of mortality in patients with acute-on-chronic liver failure&#44; and that early elevation of portal pressure may increase the risk of variceal bleeding&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Elevated portal pressures lead to systemic hemodynamic changes&#44; such as increased CO&#44; decreased peripheral vascular resistance&#44; and a reduction in MAP&#46; Our study showed that an early drop in blood pressure in ICU patients with liver failure was an independent predictor of 60-day hospitalization&#46; A 10&#8239;mmHg decrease in early SBP&#44; DBP&#44; or MAP was associated with a 14&#37;&#44; 20&#37;&#44; and 44&#37; increase in the risk of 60-day in-hospital mortality&#44; respectively&#46; Our findings suggest that an early blood pressure drop may serve as a more accessible and cost-effective predictor of prognosis than more complex measurements such as HVPGs&#46; Early peak blood pressure drop measurements are readily available in clinical practice and can provide valuable information for risk stratification and prognostic assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Additionally&#44; several studies have indicated that worse baseline renal function and AKI are independently associated with worse prognoses&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> Our study demonstrated that patients with a greater early drop in blood pressure and the development of WRF had the highest 60-day risk of in-hospital death&#44; similar to previous studies&#46; These findings present novel ideas for diagnostic and prognostic assessment&#46; However&#44; further validation and studies are warranted to confirm their clinical applications&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Our study has several strengths&#46; First&#44; this is the first study to explore the relationship between early blood pressure drops&#44; WRF&#44; and prognoses in ICU patients with liver failure&#46; Furthermore&#44; we investigated the associations between early DBP and MAP drops&#44; WRF&#44; and prognoses for the first time&#46; Second&#44; this study utilized data from the MIMIC IV database&#44; offering the advantages of a large sample size and numerous blood pressure measurements taken at short intervals&#46; Third&#44; a subgroup analysis was conducted to examine the relationship between early blood drops and renal function deterioration in different subgroups&#46; The results consistently demonstrated this association across various subgroups&#44; thus enhancing the generalizability and applicability of the findings&#46; Finally&#44; the study was adjusted for potential confounding factors&#44; including baseline blood pressure&#44; to assess the independent correlation between early blood pressure drop and outcomes&#44; thereby minimizing the impact of other factors and providing a more accurate estimation of the relationship&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Nonetheless&#44; our study had some limitations&#46; The included patients with liver failure were diagnosed using ICD-10 codes&#44; which may have introduced bias in the available information about the liver failure cohort&#46; Additionally&#44; as this was a retrospective cohort study&#44; a causal relationship between the early peak blood pressure drops and the occurrence and mortality rates of WRF could not be proven&#46; Nevertheless&#44; this large-scale cohort study utilizing a comprehensive database and multiple statistical methods demonstrated a correlation between early peak blood pressure drops and WRF&#44; offering valuable clinical reference points&#46; Finally&#44; owing to the complex interactions between diseases&#44; some confounding factors may still exist that could potentially mask or magnify the relationship between the study factors and the WRF&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Conclusions</span><p id="par0120" class="elsevierStylePara elsevierViewall">Our findings suggest a significant association between an early drop in SBP&#44; DBP&#44; and MAP within the first 48&#8239;h and the development of WRF and 60-day in-hospital mortality among ICU patients with liver failure&#46; In addition&#44; early blood pressure drops and WRF development were associated with a poorer prognosis in patients with these risk factors&#44; compared to other patients&#46; However&#44; further studies are needed to determine the causal relationship between blood pressure changes and renal function and its impact on prognoses&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0185">CRediT authorship contribution statement</span><p id="par0125" class="elsevierStylePara elsevierViewall">Rubing Guo&#58; Writing &#8211; review &#38; editing&#44; Writing &#8211; original draft&#44; Validation&#44; Supervision&#44; Project administration&#44; Methodology&#44; Investigation&#44; Formal analysis&#44; Data curation&#44; Conceptualization&#46; Jingjing Tong&#58; Methodology&#44; Investigation&#44; Formal analysis&#44; Conceptualization&#46; Li Wang&#58; Data curation&#46; Bo Yang&#58; Data curation&#46; Liang Ma&#58; Methodology&#46; Yongtong Cao&#58; Methodology&#46; Wei Zhao&#58; Methodology&#44; Investigation&#44; Formal analysis&#44; Data curation&#44; Conceptualization&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0190">Consent for publication</span><p id="par0130" class="elsevierStylePara elsevierViewall">Not applicable&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0195">Ethics approval and consent to participate</span><p id="par0135" class="elsevierStylePara elsevierViewall">Because our study was an independent research analysis of the already available MIMIC IV database&#44; no approval was obtained from our local ethics committee&#44; although it was reviewed and approved by the PhysioNet Review Board&#46; The requirement for informed consent was waived owing to the retrospective nature of the study&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0200">Funding</span><p id="par0140" class="elsevierStylePara elsevierViewall">This work was supported by the <span class="elsevierStyleGrantSponsor" id="gs0005">National High Level Hospital Clinical Research Funding</span> &#91;grant number <span class="elsevierStyleGrantNumber" refid="gs0005">2023-NHLHCRF-PY-04</span>&#93;&#59; the <span class="elsevierStyleGrantSponsor" id="gs0010">Wu Jieping Medical Foundation</span> &#91;grant number <span class="elsevierStyleGrantNumber" refid="gs0010">320&#46;6750&#46;2023-06-60</span>&#93;&#59; and the <span class="elsevierStyleGrantSponsor" id="gs0015">Research Projects of Gansu Provincial Hospital</span> &#91;grant number <span class="elsevierStyleGrantNumber" refid="gs0015">23GSSYD-25</span>&#93;&#46;</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0205">Availability of data and materials</span><p id="par0145" class="elsevierStylePara elsevierViewall">The present investigation utilized openly accessible datasets&#46; The aforementioned data can be accessed via the following link&#46; The MIMIC IV database &#40;version 2&#46;2&#41; is publicly accessible at <a href="https://mimic-iv.mit.edu">https&#58;&#47;&#47;mimic-iv&#46;mit&#46;edu</a>&#46; Researchers who comply with the stipulated data utilization requirements are granted authorization to access these databases&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">To investigate the association between early blood pressure drop and worsening renal function &#40;WRF&#41; in ICU patients with liver failure and to evaluate their clinical outcomes&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Retrospective observational study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Intensive Care Medicine&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Patients admitted to the ICU for the first time during their first hospitalization&#59; diagnosed with liver failure according to the International Classification of Diseases&#44; Ninth and Tenth Revision codes&#59; and aged &#8805;18 years were included&#46; Patients with a peak systolic blood pressure &#40;SBP&#41; drop of &#60;0&#8239;mmHg were excluded&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Intervention</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">We analyzed data of ICU patients with liver failure from the Medical Information Mart for Intensive Care IV version 2&#46;2 database&#46; Descriptive statistics&#44; analysis of variance&#44; Kruskal&#8211;Wallis test&#44; and chi-square test were employed for analysis&#46; Multivariate linear regression models were used to assess the determinants of blood pressure decline&#46; Cox proportional hazards and generalized additive models were used to evaluate</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Main variables of interest</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">The relationship between blood pressure decline&#44; WRF&#44; and 60-day in-hospital mortality were evaluated&#44; along with subgroup analyses&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Peak SBP drop was independently associated with higher risks of WRF &#40;P&#8239;&#60;&#8239;0&#46;001&#41; and 60-day in-hospital mortality &#40;P&#8239;&#60;&#8239;0&#46;001&#41;&#44; even after adjusting for potential confounders&#44; including baseline SBP&#46; The independent risk relationship observed between peak diastolic blood pressure&#44; mean arterial pressure drop&#44; and the occurrence of WRF and 60-day in-hospital mortality was similar&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">In ICU patients with liver failure&#44; a significant early drop in blood pressure was associated with a higher incidence of WRF&#44; increased risk of 60-day in-hospital mortality&#44; and poorer prognoses&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Design"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Setting"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Patients"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Intervention"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Main variables of interest"
          ]
          6 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          7 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Investigar la asociaci&#243;n entre los descensos precoces de la presi&#243;n arterial y el empeoramiento de la funci&#243;n renal &#40;EFR&#41; en pacientes de la UCI con insuficiencia hep&#225;tica y evaluar sus resultados cl&#237;nicos&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Dise&#241;o</span><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional retrospectivo&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">&#193;mbito</span><p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Medicina Intensiva&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron los pacientes ingresados en la UCI por primera vez durante su primera hospitalizaci&#243;n&#44; diagnosticados de insuficiencia hep&#225;tica seg&#250;n los c&#243;digos de la Clasificaci&#243;n Internacional de Enfermedades&#44; Novena y D&#233;cima Revisi&#243;n&#44; y con una edad &#8805;18 a&#241;os&#46; Se excluy&#243; a los pacientes con un descenso m&#225;ximo de la PAS&#8239;&#60;&#8239;0&#8239;mmHg&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenci&#243;n</span><p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">Se analizaron los datos de los pacientes de la UCI con insuficiencia hep&#225;tica de la base de datos Medical Information Mart for Intensive Care IV&#44; versi&#243;n 2&#46;2&#46; Para el an&#225;lisis se emplearon estad&#237;sticas descriptivas&#44; an&#225;lisis de varianza&#44; prueba de Kruskal&#8211;Wallis y prueba de ji-cuadrado&#46; Se utilizaron modelos de regresi&#243;n lineal multivariante para evaluar los factores determinantes del descenso de la presi&#243;n arterial&#46; Se utilizaron modelos de riesgos proporcionales de Cox y modelos aditivos generalizados para evaluar&#46; Se utilizaron modelos de riesgos proporcionales de Cox y modelos aditivos generalizados para evaluar&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables de inter&#233;s principales</span><p id="spar0145" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; la relaci&#243;n entre el descenso de la presi&#243;n arterial&#44; el EFR y la mortalidad intrahospitalaria a los 60 d&#237;as&#44; junto con an&#225;lisis de subgrupos&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0150" class="elsevierStyleSimplePara elsevierViewall">El descenso m&#225;ximo de la presi&#243;n arterial sist&#243;lica &#40;PAS&#41; se asoci&#243; de forma independiente con mayores riesgos de EFR &#40;p&#8239;&#60;&#8239;0&#44;001&#41; y mortalidad intrahospitalaria a los 60 d&#237;as &#40;p&#8239;&#60;&#8239;0&#44;001&#41;&#44; incluso tras ajustar por posibles factores de confusi&#243;n&#44; incluida la PAS basal&#46; La relaci&#243;n de riesgo independiente observada entre la presi&#243;n arterial diast&#243;lica m&#225;xima&#44; la ca&#237;da de la presi&#243;n arterial media y la aparici&#243;n de EFR y mortalidad hospitalaria a los 60 d&#237;as fue similar&#46;</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0155" class="elsevierStyleSimplePara elsevierViewall">En los pacientes de la UCI con insuficiencia hep&#225;tica&#44; una ca&#237;da precoz significativa de la presi&#243;n arterial se asoci&#243; con una mayor incidencia de EFR&#44; un mayor riesgo de mortalidad intrahospitalaria a los 60 d&#237;as y un peor pron&#243;stico&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Dise&#241;o"
          ]
          2 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "&#193;mbito"
          ]
          3 => array:2 [
            "identificador" => "abst0060"
            "titulo" => "Pacientes"
          ]
          4 => array:2 [
            "identificador" => "abst0065"
            "titulo" => "Intervenci&#243;n"
          ]
          5 => array:2 [
            "identificador" => "abst0070"
            "titulo" => "Variables de inter&#233;s principales"
          ]
          6 => array:2 [
            "identificador" => "abst0075"
            "titulo" => "Resultados"
          ]
          7 => array:2 [
            "identificador" => "abst0080"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:3 [
        "etiqueta" => "&#9674;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">These authors contributed equally&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0165" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0115"
          ]
        ]
      ]
    ]
    "multimedia" => array:7 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1485
            "Ancho" => 1500
            "Tamanyo" => 142577
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Study design and flowchart of the patient selection process&#46; SBP&#44; systolic blood pressure&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1184
            "Ancho" => 1675
            "Tamanyo" => 98957
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        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Smooth hazard plot to evaluate WRF risk across the spectrum of SBP drop in adjusted models&#46; WRF&#44; worsening renal function&#59; SBP&#44; systolic blood pressure&#59; CI&#44; confidence interval&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1819
            "Ancho" => 2175
            "Tamanyo" => 243572
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier curves for 60-day in-hospital mortality stratified by SBP drop within 48&#8239;h with&#47;without WRF&#46; SBP&#44; systolic blood pressure&#59; WRF&#44; worsening renal function&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
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        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">SBP&#44; systolic blood pressure&#59; BMI&#44; body mass index&#59; INR&#44; international normalized ratio&#59; ALT&#44; alanine aminotransferase&#59; ALP&#44; alkaline phosphatase&#59; AST&#44; aspartate aminotransferase&#59; LDH&#44; lactate dehydrogenase&#59; BUN&#44; blood urea nitrogen&#59; SPO<span class="elsevierStyleInf">2</span>&#44; oxygen saturation&#59; CKD&#44; chronic kidney disease&#59; DBP&#44; diastolic blood pressure&#59; MAP&#44; mean arterial pressure&#59; WRF&#44; worsening renal function&#46;</p>"
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                  \t\t\t\t" scope="col">Characteristics</th><th class="td-with-role" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Low tertile &#40;0&#8722;23&#8239;mm Hg&#41; &#40;N&#8239;&#61;&#8239;331&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medium tertile &#40;23&#8722;39&#8239;mm Hg&#41; &#40;N&#8239;&#61;&#8239;354&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">High tertile &#40;39&#8722;140&#8239;mm Hg&#41; &#40;N&#8239;&#61;&#8239;354&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Age &#40;y&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">58&#46;0&#8239;&#177;&#8239;15&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">60&#46;4&#8239;&#177;&#8239;14&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">62&#46;2&#8239;&#177;&#8239;15&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Sex &#40;Male&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">221 &#40;62&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">211 &#40;59&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;731&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30&#46;5&#8239;&#177;&#8239;6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30&#46;3&#8239;&#177;&#8239;6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#46;4&#8239;&#177;&#8239;7&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;960&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Race&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;066&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">205 &#40;61&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">210 &#40;59&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">189 &#40;53&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Other&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">126 &#40;38&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">165 &#40;46&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Laboratory parameters</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">1&#46;8 &#40;1&#46;4&#8722;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;8 &#40;1&#46;4&#8722;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;283&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ALT &#40;U&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">88&#46;0 &#40;30&#46;0&#8722;468&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">80&#46;8 &#40;30&#46;1&#8722;352&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">117&#46;5 &#40;35&#46;1&#8722;581&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;041&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">123&#46;5 &#40;82&#46;2&#8722;184&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">114&#46;8 &#40;76&#46;0&#8722;172&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">108&#46;0 &#40;74&#46;8&#8722;159&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AST &#40;U&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">192&#46;0 &#40;69&#46;5&#8722;883&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">170&#46;8 &#40;65&#46;0&#8722;629&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">237&#46;8 &#40;71&#46;2&#8722;927&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LDH &#40;U&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">546&#46;0 &#40;310&#46;5&#8722;1111&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">498&#46;3 &#40;325&#46;7&#8722;900&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">654&#46;5 &#40;353&#46;3&#8722;1334&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total bilirubin &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;0 &#40;1&#46;2&#8722;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2&#46;7 &#40;1&#46;0&#8722;6&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0 &#40;0&#46;9&#8722;5&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BUN &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#46;5 &#40;17&#46;5&#8722;48&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;5 &#40;17&#46;0&#8722;50&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;5 &#40;18&#46;0&#8722;46&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Creatinine &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5 &#40;0&#46;9&#8722;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;4 &#40;1&#46;0&#8722;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7 &#40;1&#46;1&#8722;2&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;306&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Potassium &#40;mmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;4&#8239;&#177;&#8239;0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;4&#8239;&#177;&#8239;0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;6&#8239;&#177;&#8239;0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sodium &#40;mmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&#46;6&#8239;&#177;&#8239;6&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#46;5&#8239;&#177;&#8239;6&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">138&#46;0&#8239;&#177;&#8239;6&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vital signs</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Respiratory rate &#40;breaths&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;9&#8239;&#177;&#8239;4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;6&#8239;&#177;&#8239;4&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;4&#8239;&#177;&#8239;5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart rate &#40;beats&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#46;9&#8239;&#177;&#8239;16&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#46;1&#8239;&#177;&#8239;17&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#46;2&#8239;&#177;&#8239;18&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Temperature &#40;&#8451;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;8&#8239;&#177;&#8239;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;8&#8239;&#177;&#8239;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;8&#8239;&#177;&#8239;0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;533&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SPO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;2&#8239;&#177;&#8239;3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;5&#8239;&#177;&#8239;2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;1&#8239;&#177;&#8239;3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coexisting illness</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;26&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108 &#40;30&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97 &#40;27&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;25&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">109 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;24&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79 &#40;23&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;25&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;33&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CKD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;16&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72 &#40;20&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82 &#40;23&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Respiratory failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">177 &#40;53&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192 &#40;54&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">204 &#40;57&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;503&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baseline SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#46;3&#8239;&#177;&#8239;15&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114&#46;6&#8239;&#177;&#8239;14&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&#46;4&#8239;&#177;&#8239;24&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baseline DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;8&#8239;&#177;&#8239;13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;7&#8239;&#177;&#8239;13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;7&#8239;&#177;&#8239;19&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baseline MAP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;6&#8239;&#177;&#8239;12&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;7&#8239;&#177;&#8239;11&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;3&#8239;&#177;&#8239;19&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>WRF through day 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">143 &#40;43&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">172 &#40;48&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">198 &#40;55&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Death through day 60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112 &#40;33&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142 &#40;40&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">181 &#40;51&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3700935.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics of patients stratified by peak SBP drop tertiles &#40;within first 48&#8239;h&#41;&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Non-adjusted model considered&#58; none&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Model I was adjusted for baseline SBP&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Model II was adjusted for age&#44; sex&#44; baseline SBP&#44; total bilirubin&#44; creatinine&#44; potassium&#44; respiratory rate&#44; heart rate&#44; and respiratory failure&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">SBP&#44; systolic blood pressure&#59; WRF&#44; worsening renal function&#59; HR&#44; hazard ratio&#59; CI&#44; confidence interval&#46;</p>"
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            0 => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Exposure</th><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non-adjusted model</th><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Model I</th><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Model II</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peak SBP drop &#40;per 10&#8239;mmHg drop&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;05 &#40;1&#46;01&#44; 1&#46;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;15 &#40;1&#46;10&#44; 1&#46;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;08 &#40;1&#46;03&#44; 1&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peak SBP drop tertile</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Low&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00 &#40;Ref&#46;&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00 &#40;Ref&#46;&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00 &#40;Ref&#46;&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Middle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;14 &#40;0&#46;92&#44; 1&#46;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;242&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;35 &#40;1&#46;07&#44; 1&#46;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;26 &#40;1&#46;00&#44; 1&#46;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;047&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>High&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;44 &#40;1&#46;16&#44; 1&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;12 &#40;1&#46;66&#44; 2&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;63 &#40;1&#46;26&#44; 2&#46;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>P for trend&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Association between peak SBP drop &#40;per 10&#8239;mmHg&#41; within 48&#8239;h from baseline and WRF&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0030"
            "detalle" => "Table "
            "rol" => "short"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Non-adjusted model considered&#58; none&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Model I was adjusted for baseline SBP&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Model II was adjusted for age&#44; sex&#44; baseline SBP&#44; total bilirubin&#44; creatinine&#44; potassium&#44; respiratory rate&#44; heart rate&#44; and respiratory failure&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">SBP&#44; systolic blood pressure&#59; WRF&#44; worsening renal function&#59; HR&#44; hazard ratio&#59; CI&#44; confidence interval&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Exposure</th><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non-adjusted model</th><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Model I</th><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Model II</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peak SBP drop &#40;per 10&#8239;mmHg drop&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;09 &#40;1&#46;05&#44; 1&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;20 &#40;1&#46;14&#44; 1&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;14 &#40;1&#46;09&#44; 1&#46;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peak SBP drop median</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SBP drop&#8239;&#8804;&#8239;median without WRF&nbsp;\t\t\t\t\t\t\n
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        "identificador" => "xack784149"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0155" class="elsevierStylePara elsevierViewall">We extend our sincere gratitude to the team at the Laboratory for Computational Physiology &#40;LCP&#41; of the Massachusetts Institute of Technology &#40;MIT&#41; for providing the invaluable MIMIC-IV database&#46; Their efforts have greatly facilitated our research in the medical field&#44; and we truly appreciate their contributions&#46;</p>"
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    ]
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