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Original article
Available online 31 July 2026

Effectiveness of silver ion controlled release antimicrobial compound in reducing multi-drug-resistant microorganism contamination in an intensive care unit: An interventional proof-of-concept study

Eficacia de un compuesto antimicrobiano de liberación controlada de iones de plata en la reducción de la contaminación por microorganismos multirresistentes en una unidad de cuidados intensivos: un estudio de intervención de prueba de concepto
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Paula Ramireza,
Corresponding author
Ramirez_pau@gva.es

Corresponding author.
, Juan Frasquetb, Sergio Fernandezc, Héctor Martínezc, María Fortezaa, Esther Benamud, Trinidad Sancheza, Hugo Arrandoa, Blanca Garcia-Roiga, Eva Gonzálezb, Álvaro Castellanos-Ortegaa
a Critical Care Department, Hospital Universitario y Politécnico la Fe, Valencia, Spain
b Microbiology Department, Hospital Universitario y Politécnico la Fe, Valencia, Spain
c Preventive Medicine Department, Hospital Universitario y Politécnico la Fe, Valencia, Spain
d Division of Transplant and Infectious diseases, North Shore University Hospital, Spain
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Abstract
Objectives

Environmental contamination plays a key role in the transmission of multidrug-resistant microorganisms (MDRMs) in intensive care units (ICUs). We evaluated the effectiveness of a silver ion–controlled release antimicrobial compound applied to ICU surfaces in reducing environmental contamination and patient colonization.

Design

Quasi-experimental study with a concurrent control group.

Setting

A 24-bed ICU divided into two identical subunits.

Participants

All patients admitted to the ICU during the study period.

Interventions

One subunit followed standard disinfection procedures (control unit), while the other used standard disinfection plus monthly application of a silver ion–controlled release antimicrobial compound (NOB166®) to high-touch surfaces (intervention unit).

Variables of interest

Environmental surface cultures and patient surveillance cultures were obtained weekly over a 5-month period.

Results

A total of 506 environmental samples were collected. MDRMs were detected in 22/256 samples (8.5%) from the control unit compared with 8/250 samples (3.2%) from the intervention unit (P = .01). MDRM acquisition occurred in 19/127 patients (14.9%) in the control unit and 10/168 patients (5.9%) in the intervention unit (P < .01). Acinetobacter baumannii and Candida auris were the most frequently isolated organisms. Two MDRM outbreaks occurred in the control unit, whereas none were detected in the intervention unit. Rates of nosocomial infection did not differ significantly between groups.

Conclusions

The use of a silver ion–controlled release antimicrobial surface coating was associated with a significant reduction in environmental MDRM contamination and patient colonization in ICU. These findings support the role of long-acting antimicrobial surface treatments as adjuncts to standard infection prevention strategies.

Keywords:
Silver compounds
Critical care
Colonization
Multi-drug-resistant microorganisms
Disinfection
Resumen
Objetivos

Evaluamos la eficacia de un recubrimiento antimicrobiano de liberación controlada de iones de plata aplicado a superficies de la UCI para reducir la contaminación ambiental y la colonización de los pacientes.

Diseño

Estudio cuasi experimental con grupo control concurrente.

Ámbito

UCI de 24 camas dividida en dos subunidades idénticas.

Participantes

Todos los pacientes ingresados en la UCI durante el período de estudio.

Intervenciones

Una subunidad siguió los procedimientos estándar de desinfección (unidad control, UC), mientras que en la otra se añadió la aplicación mensual de un recubrimiento antimicrobiano de liberación controlada de iones de plata (NOB166®) sobre superficies de alto contacto (unidad de intervención, UI).

Variables de interés

Cultivos ambientales de superficies y cultivos de vigilancia semanales en pacientes durante 5 meses.

Resultados

Se obtuvieron 506 muestras ambientales. Se detectaron MMR en 22/256 muestras (8,5%) de la UC frente a 8/250 (3,2%) de la UI (P = ,01). La adquisición de MMR ocurrió en 19/127 pacientes (14,9%) de la UC y en 10/168 (5,9%) de la UI (P < ,01). Acinetobacter baumannii y Candida auris fueron los microorganismos aislados con mayor frecuencia. Se registraron dos brotes de MMR en la UC y ninguno en la UI. Las tasas de infección nosocomial no difirieron entre grupos.

Conclusiones

El uso de un recubrimiento antimicrobiano de liberación controlada de iones de plata se asoció con una reducción significativa de la contaminación ambiental por MMR y de la colonización de los pacientes en la UCI, respaldando su empleo como estrategia complementaria para su control.

Palabras clave:
Compuestos de plata
Cuidados críticos
Colonización
Microorganismos multirresistentes
Desinfección

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