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Original article
Available online 30 December 2021
Multicenter validation of Early Warning Scores for detection of clinical deterioration in COVID-19 hospitalized patients
Validación multicéntrica de Sistemas de Alerta Temprana para la detección precoz de deterioro clínico en pacientes hospitalizados por COVID-19
I.A. Huespea,b,c,
Corresponding author
, I.C. Bissoa, E.S. Romana, E. Pradoa,d, N. Gemellia, J. Sinnera, M.L. Herasa, M.R. Riskb
a Intensive Care Unit, Hospital Italiano de Buenos Aires, Argentina
b Instituto de Medicina Traslacional e Ingeniería Biomédica, HIBA, IUHI, CONICET, Buenos Aires, Argentina
c Internal Medicine Research Unit, Hospital Italiano de Buenos Aires, CABA, Argentina
d Instituto de ciencias aplicadas Sergio Provenzano (ICAP), Facultad de Medicina, Universidad de Buenos Aires, Argentina
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Tables (3)
Table 1. Baseline characteristics of patients at hospital admission.
Table 2. Characteristics of patients 24h before ICU admission. In non-ICU patient's data was compared on the second day of hospitalization.
Table 3. AUROCs and 95% Confidence intervals of the NEWS2, NEWS-C and COVID-19 Severity Index 24 and 48h prior ICU transfer.
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Additional material (1)

Investigate the predictive value of NEWS2, NEWS-C, and COVID-19 Severity Index for predicting intensive care unit (ICU) transfer in the next 24h.


Retrospective multicenter study.


Two third-level hospitals in Argentina.


All adult patients with confirmed COVID-19, admitted on general wards, excluding patients with non-intubated orders.


Patients were divided between those who were admitted to ICU and non-admitted. We calculated the three scores for each day of hospitalization.


We evaluate the calibration and discrimination of the three scores for the outcome ICU admission within 24, 48h, and at hospital admission.


We evaluate 13,768 days of hospitalizations on general medical wards of 1318 patients. Among these, 126 (9.5%) were transferred to ICU. The AUROC of NEWS2 was 0.73 (95%CI 0.68–0.78) 24h before ICU admission, and 0.52 (95%CI 0.47–0.57) at hospital admission. The AUROC of NEWS-C was 0.73 (95%CI 0.68–0.78) and 0.52 (95%CI 0.47–0.57) respectively, and the AUROC of COVID-19 Severity Index was 0.80 (95%CI 0.77–0.84) and 0.61 (95%CI 0.58–0.66) respectively. COVID-19 Severity Index presented better calibration than NEWS2 and NEWS-C.


COVID-19 Severity index has better calibration and discrimination than NEWS2 and NEWS-C to predict ICU transfer during hospitalization.

Early Warning Score
Critical care

Investigar el valor predictivo de los scores NEWS2, NEWS-C y COVID-19 Severity Index para predecir la transferencia de urgencia a la unidad de cuidados intensivos (UCI) en las próximas 24horas.


Estudio multicéntrico retrospectivo.


Dos hospitales de tercer nivel en Argentina.


Pacientes adultos con COVID-19, ingresados en salas generales, excluyendo pacientes con órdenes de no intubar.


Se dividió a los pacientes entre los que ingresaron en la UCI y los que no ingresaron. Calculamos las tres puntuaciones para cada día de hospitalización.


Evaluamos la calibración y discriminación de las tres puntuaciones para predecir el traslado de urgencia a UCI en las 24, 48h previas al pase a UCI y al ingreso hospitalario.


Evaluamos 13.768 días de hospitalización en internación general de 1.318 pacientes, de los cuales 126 (9,5%) fueron trasladados a UCI. El AUROC del NEWS2 fue de 0,73 (IC 95% 0,68-0,78) 24h antes del ingreso en UCI y de 0,52 (IC 95% 0,47-0,57) al ingreso hospitalario. El AUROC de NEWS-C fue de 0,73 (IC 95% 0,68-0,78) y 0,52 (IC 95% 0,47-0,57) respectivamente, y el AUROC del COVID-19 Severity Index fue de 0,80 (IC 95% 0,77-0,84) y 0,61 (IC 95% 0,58-0,66) respectivamente. El COVID-19 Severity Index presentó una mejor calibración que NEWS2 y NEWS-C.


El COVID-19 Severity Index presentó una mejor calibración y discriminación que NEWS2 y NEWS-C para predecir la transferencia de la UCI durante la hospitalización.

Palabras clave:
Sistemas de alerta temprana
Cuidados intensivos


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