Observation of opioid and sedative weaning and iatrogenic withdrawal syndrome practices in patients receiving invasive mechanical ventilation

Bolesta, Scott; Burry, Lisa; Perreault, Marc M.; Gélinas, Céline; Smith, Kathryn E.; Carini, Federico C.; Eadie, Rebekah; Riker, Richard R.; Erstad, Brian L.

doi:10.1016/j.medine.2026.502627

Medicina Intensiva (English Edition)

ISSN: 2173-5727

Medicina Intensiva is the journal of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC), and has become the reference publication in Spanish in its field. Medicina Intensiva mainly publishes Original Articles, Reviews, Clinical Notes, Images in Intensive Medicine, and Information relevant to the specialty. All works go through a rigorous selection process.

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Bolesta S, Burry L, Perreault MM, Gélinas C, Smith KE, Carini FC, et al. Observation of opioid and sedative weaning and iatrogenic withdrawal syndrome practices in patients receiving invasive mechanical ventilation. https://doi.org/10.1016/j.medine.2026.502627

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Observation of opioid and sedative weaning and iatrogenic withdrawal syndrome practices in patients receiving invasive mechanical ventilation

Observación de las prácticas de retirada de opioides y sedantes y del síndrome de abstinencia iatrogénica en pacientes sometidos a ventilación mecánica invasiva

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Scott Bolestaa,

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scott.bolesta@wilkes.edu

Corresponding author.

, Lisa Burryb, Marc M. Perreaultc, Céline Gélinasd, Kathryn E. Smithe, Federico C. Carinif, Rebekah Eadieg, Richard R. Rikerh, Brian L. Erstadi, on behalf of the ALERT-ICU study investigators

a Department of Pharmacy Practice, Nesbitt School of Pharmacy, Wilkes University, Wilkes-Barre, PA, United States

b Departments of Pharmacy and Medicine, Sinai Health System and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada

c Department of Pharmacy, McGill University Health Center and Faculty of Pharmacy, University of Montréal, Montréal, Canada

d Ingram School of Nursing, McGill University, and Centre for Nursing Research/Lady Davis Institute, Jewish General Hospital – CIUSSS West-Central-Montréal, Montréal, Canada

e Pharmacy, Maine Medical Center, Portland, ME, United States

f MS-ICU, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

g Critical Care/Pharmacy, Ulster Hospital, Dundonald, United Kingdom

h Department of Critical Care/Pulmonary Medicine, Maine Medical Center, Portland, ME, United States

i Department of Pharmacy Practice and Science, The University of Arizona, Tucson, AZ, United States

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Observation of opioid and sedative weaning and iatrogenic withdrawal syndrome practices in patients receiving invasive mechanical ventilation

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