In recent years, artificial intelligence (AI) has spread across the world, rapidly changing it and affecting all levels of human activity. One of these areas is undoubtedly biomedical research. This is evident in the growing number of articles using AI tools to analyze reality and being published in biomedical journals. AI has also been incorporated throughout the article generation process, including the literature review, hypothesis generation, analysis method, and manuscript presentation and style correction. Journal managers and researchers must minimize the inherent risks of dishonest use of these technologies through ethical commitment on the part of researchers. However, transparency of use must be combined with clear rules and strict control, as well as consequences for fraudulent use. The dual nature of AI, which provides access to associations and processes that are unattainable to humans while also generating uncertain information, requires a commitment from everyone involved in scientific dissemination. In this special supplement, we have compiled original articles, editorials, and points of view published between January 1, 2024, and December 31, 2026, that use these techniques to leverage their analytical power.