TY - JOUR T1 - Preemptive hemodynamic intervention restricting the administration of fluids attenuates lung edema progression in oleic acid-induced lung injury JO - Medicina Intensiva T2 - AU - Gil Cano,A. AU - Gracia Romero,M. AU - Monge García,M.I. AU - Guijo González,P. AU - Ruiz Campos,J. SN - 02105691 M3 - 10.1016/j.medin.2016.08.008 DO - 10.1016/j.medin.2016.08.008 UR - https://www.medintensiva.org/es-preemptive-hemodynamic-intervention-restricting-administration-articulo-S021056911630184X AB - ObjectiveA study is made of the influence of preemptive hemodynamic intervention restricting fluid administration upon the development of oleic acid-induced lung injury. DesignA randomized in vivo study in rabbits was carried out. SettingUniversity research laboratory. SubjectsSixteen anesthetized, mechanically ventilated rabbits. VariablesHemodynamic measurements obtained by transesophageal Doppler signal. Respiratory mechanics computed by a least square fitting method. Lung edema assessed by the ratio of wet weight to dry weight of the right lung. Histological examination of the left lung. InterventionsAnimals were randomly assigned to either the early protective lung strategy (EPLS) (n=8) or the early protective hemodynamic strategy (EPHS) (n=8). In both groups, lung injury was induced by the intravenous infusion of oleic acid (OA) (0.133mlkg−1h−1 for 2h). At the same time, the EPLS group received 15mlkg−1h−1 of Ringer lactate solution, while the EPHS group received 30mlkg−1h−1. Measurements were obtained at baseline and 1 and 2h after starting OA infusion. ResultsAfter 2h, the cardiac index decreased in the EPLS group (p<0.05), whereas in the EPHS group it remained unchanged. Lung compliance decreased significantly only in the EPHS group (p<0.05). Lung edema was greater in the EPHS group (p<0.05). Histological damage proved similar in both groups (p=0.4). ConclusionsIn this experimental model of early lung injury, lung edema progression was attenuated by preemptively restricting the administration of fluids. ER -