TY - JOUR T1 - Blood caspase-8 concentrations and mortality among septic patients JO - Medicina Intensiva T2 - AU - Lorente,L. AU - Martín,M.M. AU - Ortiz-López,R. AU - González-Rivero,A.F. AU - Pérez-Cejas,A. AU - Martín,M. AU - Gonzalez,V. AU - Pérez,A. AU - Rodin,M. AU - Jiménez,A. SN - 02105691 M3 - 10.1016/j.medin.2020.06.016 DO - 10.1016/j.medin.2020.06.016 UR - https://www.medintensiva.org/es-blood-caspase-8-concentrations-mortality-among-articulo-S0210569120302461 AB - ObjectiveNo data are available on blood caspase-8 concentrations (the initiator caspase in the extrinsic apoptosis pathway) in septic patients. The present study thus describes the blood caspase-8 concentrations in survivors and non-survivors, and examines the possible association between blood caspase-8 concentrations and mortality in septic patients. DesignA prospective observational study was carried out. SettingThree Spanish Intensive Care Units. PatientsSeptic patients. InterventionsSerum caspase-8 concentrations were determined at the diagnosis of sepsis. Main variable of interestMortality after 30 days. ResultsPatients not surviving at day 30 (n=81) compared to surviving patients (n=140) showed higher serum caspase-8 levels (p<0.001). Multiple logistic regression analysis found an association between serum caspase-8 levels>43.5ng/ml and mortality (OR=3.306; 95%CI=1.619–6.753; p=0.001). The area under the curve (AUC) for mortality predicted by serum caspase-8 levels was 67% (95% CI=60–73%; p<0.001). ConclusionsThe novel findings of our study were that blood caspase-8 concentrations are higher in non-survivors than in survivors, and that there is an association between blood caspase-8 concentrations and mortality in septic patients. ER -