Graphical Review8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions
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Graphical abstract
Binding of OGG1 to genomic 8-oxoguanine facilitates gene expression. Proposed actions of OGG1 on open chromatin region (left), OGG1 binding to its substrate facilitates DNA occupancy of transcription factors (NF-κB is shown as example) and promote transcription. If guanine oxidation occurs at closed chromatin region (right), binding of OGG1 could block the interaction of methyl binding proteins (BMPs) with their substrates, subsequently recruit transcription machinery components to activate transcription.
Abbreviations
ROS
reactive oxygen species
8-oxoG
7, 8-dihydro-8-oxoguanine
OGG1
8-oxoguanine DNA glycosylase 1
BER
base excision repair
OGG1-BER
OGG1-initiated DNA base excision repair
IIR
innate immune response
TNFα
Tumor necrosis factor alpha
NF-κB
Nuclear Factor kappa B
Sp1
specificity protein1
AP-1
activator protein 1
STAT1
signal transducer and activator of transcription 1
(Me)C
methylation of cytosine
MBPs
methyl-CpG-binding proteins
Keywords
OGG1
8-oxoguanine
Gene expression regulation
Epigenetic
DNA methylation
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© 2017 The Authors. Published by Elsevier B.V.