Original articleIL6 gene-wide haplotype is associated with susceptibility to acute lung injury
Section snippets
Subjects, definitions, and study design
This study was approved by the Hospital Universitario N.S. de Candelaria (Canary Islands, Spain) Ethics Committee. The association of IL6 gene variants with ALI was evaluated using a European case-control sample that included 96 population-based controls drawn from a large representative cohort of the general population.24 Patients with severe sepsis derived-ALI were admitted into the postsurgical and intensive care units of the hospital. Patients were admitted within 24 h of the diagnosis of
Results
A total of 67 patients who fulfilled the criteria for severe sepsis and ALI were enrolled in the study. Demographic and clinical features from patients and controls are summarized in Table I. The overall ICU mortality was 44.1%.
The −174G/C SNP was not significantly associated with ALI in this sample of sepsis-induced ALI patients, which demonstrated an unadjusted odds ratio (OR) of 1.09 [95% confidence interval (CI), 0.66–1.80; P = 0.73] (Table II). After testing an additional set of 14 IL6
Discussion
We attempted to replicate prior associations of IL6 gene with ALI susceptibility using similar numbers of case-control samples.19, 20, 21 Unlike 2 of these studies,19, 21 we did not find −174G/C SNP to be individually associated with ALI. The other 14 tSNPs of the gene also were not significantly associated with ALI, and an exploration of different genotype-based tests did not alter this result as the best uncorrected P-value obtained was 0.049 (for the SNP at −572 in a codominant model), which
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Cited by (0)
C.F. and S-F.M. contributed equally to this work.
Supported by NHLBI HL58064 and HL 073994, by the Lowell Coggeshall Endowment, and by the Fundación Canaria Dr. Manuel Morales (to C.F.).