Original Article/TransplantationEarly lactate clearance as a reliable predictor of initial poor graft function after orthotopic liver transplantation
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Early postoperative mortality in liver transplant recipients involving indications other than hepatocellular carcinoma. A retrospective cohort study
2021, Medicina IntensivaCitation Excerpt :Pretransplant serum creatinine is a well-known predictor of postransplant mortality33–34 but has collinearity with MELD-Na, which was expected since serum creatinine is contained in the MELD-Na. Also, blood lactic acid levels tested just after transplantation could also be considered a risk factor, although its clearance is more important than the postoperative peak.35–36 There are several aspects for practical application of our results.
Is Lactic Acidosis After Lung Transplantation Associated With Worse Outcomes?
2020, Annals of Thoracic SurgeryThe incidence and outcome of hyperlactatemia in patients admitted to the intensive care unit after elective surgery
2018, American Journal of SurgeryCitation Excerpt :However, hyperlactatemia in patients admitted to the ICU for monitoring and observation after elective surgery, who have lower expected mortality compared with other critically ill patients, has not been studied previously. There have been a few studies for hyperlactatemia in postoperative patients such as major abdominal surgery,13–15 colorectal perforation,16 hepatectomy17,18 and liver transplantation.19 In these studies, hyperlactatemia was associated with adverse events, e.g., acute kidney injury in the SICU,15 anastomotic leakage, hyperbilirubinemia, intraabdominal abscess after hepatectomy,17,18 and early poor graft function after liver transplantation.19
Impact of real-time metabolomics in liver transplantation: Graft evaluation and donor-recipient matching
2018, Journal of HepatologyBioenergetic adaptations of the human liver in the ALPPS procedure – how liver regeneration correlates with mitochondrial energy status
2017, HPBCitation Excerpt :Arterial lactate was measured every 6 h in the first 24 h. Standard biochemical determinations of International Normalized Ratio (INR), total bilirubin, alanine-aminotransferase (ALT) and aspartate-aminotransferase (AST) were performed every day until discharge. Arterial lactate clearance was calculated according to Wu et al.28 In ALPPS patients glutamate dehydrogenase (GLDH) was assessed on postoperative days 1, 2 and 3 with a GLDH assay kit (Sigma–Aldrich) on Enzyme Linked Immunosorbent Assay. Normality of distribution was confirmed with the Shapiro–Wilk test.