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Original article
Available online 28 April 2025
Triglyceride-Glucose Index as a predictor of severity in acute pancreatitis: Systematic Review and Meta-Analysis
Índice triglicéridos-glucosa como predictor de gravedad en pancreatitis aguda: revisión sistemática y metaanálisis
Gustavo Adolfo Vásquez-Tiradoa,
Corresponding author
gavt13@gmail.com

Corresponding author.
, Odett Yamile Aguirre-Varasa, Edinson Dante Meregildo-Rodríguezb, Claudia Vanessa Quispe-Castañedaa, Wilson Marcial Guzmán-Aguilarc, Leslie Jacqueline Liñán-Díaza, Luis Ángel Rodríguez-Cháveza
a Facultad de Medicina Humana, Universidad Privada Antenor Orrego, Trujillo, Peru
b Escuela de Posgrado, Universidad Señor de Sipán, Lambayeque, Peru
c Facultad de Medicina, Universidad Nacional de Trujillo, Trujillo, Peru
Received 05 February 2025. Accepted 20 March 2025
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Table 1. General characteristics of included studies.
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Table 2. NOS for risk of bias and quality assessment of non-randomized studies (NRS).
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Abstract
Objective

The triglyceride-glucose (TyG) index has been proposed as a novel predictive variable of severe acute pancreatitis (SAP)

Design

Systematic review and meta-analysis.

Setting

A comprehensive search was conducted across five databases of studies published up to March 17, 2024, using the PECO strategy. Seven studies were identified and included in our meta-analysis.

Participants

The participants of the included primary studies (non-severe acute pancreatitis).

Interventions

High triglyceride-glucose (TyG) index

Main variables of interest

Severe acute pancreatitis,

Results

Our analysis evaluated the risk of progression to severity in patients with elevated TyG index in acute pancreatitis through four non-randomized studies. The TyG index was found to be a predictor of severity in acute pancreatitis, with an overall severity risk (OR: 2.38; 95% CI: 1.50–4.08; I²: 80%). Additionally, the analysis of the standardized mean difference (SMD) across all seven studies between patients with SAP and non-SAP yielded an overall mean (OR: 0.90; 95% CI: 0.70–1.11; I²: 28%).

Conclusion

In patients with acute pancreatitis, a TyG index is a predictor of severity.

Keywords:
Triglyceride-glucose index (TyG)
Severe acute pancreatitis
Prognostic
Systematic review
Meta-analysis
Resumen
Objetivo

El índice triglicéridos-glucosa (TyG) ha surgido como un posible marcador predictivo para pancreatitis aguda grave (PAG).

Diseño

Este estudio corresponde a una revisión sistemática y un metaanálisis.

Ámbito

Se realizó una búsqueda exhaustiva en cinco bases de datos para identificar estudios publicados hasta el 17 de marzo de 2024, utilizando la estrategia PECO. Siete estudios fueron seleccionados e incluidos en el metaanálisis.

Participantes

Pacientes diagnosticados con pancreatitis aguda en estudios primarios, excluyendo aquellos con formas graves de la enfermedad al inicio.

Intervención

Índice triglicéridos-glucosa (TyG) elevado.

Variables de interés principales

Pancreatitis aguda grave.

Resultados

Nuestro análisis evaluó el riesgo de progresión a gravedad en pacientes con un índice TyG elevado mediante cuatro estudios no aleatorizados. El índice TyG se identificó como un predictor de gravedad en la pancreatitis aguda, con un riesgo general de severidad (OR: 2.38; IC 95%: 1.50–4.08; I²: 80%). Además, el análisis de la diferencia de medias estandarizada (SMD) entre los pacientes con PAG y aquellos sin PAG, a través de los siete estudios incluidos, arrojó una media global (OR: 0.90; IC 95%: 0.70–1.11; I²: 28%).

Conclusión

En pacientes con pancreatitis aguda, el índice TyG es un predictor de gravedad.

Palabras clave:
Índice triglicéridos-glucosa (TyG)
Pancreatitis aguda grave
Pronóstico
Revisión sistemática
Metaanálisis

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